Specialized anti-corruption agencies (ACAs) aim to address corruption problems when conventional institutional mechanisms are dysfunctional. Yet, we still lack thorough understanding of the conditions that enable ACAs to withstand undue influences of the overarching political regime. Informed by the judicial politics literature, we examine the value of public opinion in empowering ACAs. Leveraging the evolving political conditions of Hong Kong, we argue that a lack of public support for other government organs offers opportunities for an ACA to distinguish itself from the rest of the regime and establish operational independence. We find that a signature ACA of Hong Kong, created by the British colonial government, has been uniquely sensitive to public complaints of corruption. The agency is the most responsive when other government branches are perceived to be lacking integrity. Also, negative appraisals of the political regime encourage the ACA’s institutional functions and increase the degree of enforcement discretion entrusted to it. Our findings suggest a mechanism of ACA empowerment whereby the public is committed to sustaining agency independence because of their distrust and the unpopularity of other government organs. Therefore, potential institutional threats posed by an unpopular regime to the ACA may actually strengthen the latter’s power and autonomy.