Kyle Harper's article on the “Plague of Cyprian” that appeared in this journal in 2015 constitutes the only comprehensive study to date of this important disease outbreak in the third quarter of the 3rd c. CE. The current article revisits the main evidence for this epidemic and corrects and improves our understanding of its origin, timeline, and spread. It contends that the disease entered the Roman Empire via Gothic invasions on the Danube rather than traveling up the Nile from inner Africa. It further argues that the disease reached the Roman Empire only after the death of Decius and cannot be connected with the latter's edict commanding sacrifices to the Roman gods, issued in 249 CE. While the pestilence indubitably exacerbated the political and military crisis of the third quarter of the 3rd c. CE, it should probably not be considered as the root of the crisis itself, as Harper has suggested.