Flumioxazin plus metolachlor mixtures preemergence (PRE) were evaluated with or without postemergence (POST) herbicides for weed control and peanut (Arachis hypogaea) response in three North Carolina studies. Metolachlor PRE at 2.24 kg ai/ha controlled goosegrass (Eleusine indica) and yellow nutsedge (Cyperus esculentus) 93 and 80%, respectively, and control was not improved with flumioxazin or norflurazon. Metolachlor plus flumioxazin PRE at 0.07 or 0.11 kg ai/ha controlled common lambsquarters (Chenopodium album); entireleaf (Ipomoea hederacea var. integriuscula), ivyleaf (I. hederacea), and pitted morningglory (I. lacunosa); and prickly sida (Sida spinosa) better than metolachlor plus norflurazon PRE at 1.34 kg ai/ha. Morningglories (Ipomoea spp.) were controlled 77 and 86% with flumioxazin PRE at 0.07 and 0.11 kg/ha, respectively, and control was increased to nearly 100% with acifluorfen plus 2,4-DB or lactofen plus 2,4-DB POST. Peanut injury by flumioxazin and norflurazon was observed at one location in 1997; however, yields were not reduced. Peanut treated with metolachlor plus flumioxazin PRE at either rate yielded at least 3,750 kg/ha compared to 3,120 kg/ha with metolachlor plus norflurazon PRE or 1,320 kg/ha with metolachlor PRE.