Imazethapyr was evaluated PRE and POST in five lettuce types and chicory under Florida field conditions. The relative sensitivity of leafy crop vigor (most sensitive to most tolerant) to imazethapyr PRE, based on 20% inhibition determined using regression analysis, was as follows: Boston > bibb > crisphead > romaine > leaf > escarole > endive. Leafy crop injury increased as the rate of imazethapyr applied POST increased, with all leafy crops responding in a similar manner. Surfactant addition increased imazethapyr phytotoxicity. Imazethapyr PRE treatments at 0.067 kg ai/ha provided greater than 80% control of livid amaranth, common purslane, flatsedge, and common lambsquarters. Imazethapyr POST at 0.067 kg/ha, with surfactant provided control greater than 85% of all weed species. Greater than 85% spiny amaranth control was provided by imazethapyr POST at 0.017 kg/ha. Use of surfactant with imazethapyr did not improve spiny amaranth control over imazethapyr with no surfactant. POST treatments did not decrease leafy crop yield compared with the hand-weeded check. Imazethapyr applied PRE reduced crop yield compared to the POST treatments and the hand-weeded control.