Barnyardgrass and many broadleaf weeds were severely stunted by POST applications of isoxaben. Most grasses were only moderately affected by isoxaben at rates up to 1 kg/ha. POST activity was enhanced by soil interception, but evident with foliar interception alone. Cell swelling in stems and in interveinal leaf lamina was observed after foliar application. A radiotracer study in redroot pigweed showed that only a small amount (3.3% of applied) of isoxaben entered the leaf following foliar application, and that little (0.08% of applied) isoxaben migrated beyond the point of application. The potential of isoxaben as a POST herbicide may be limited, in part, by poor absorption and translocation.