This paper introduces the two factors of temporality and interaction, which are not well-researched within the Turkey-EU relationship. I suggest that these two factors are important for understanding the process of Europeanization in Turkey and explaining the ups and downs in the long-lasting relationship. After briefly examining the two historical periods of the Turkey-EU relationship — that is, from 1959 to 1970 and from 1970 to 1999 — the paper mainly focuses on the more recent period following the Helsinki Summit of 1999 and shows how the factors of temporality and interaction operated differently between 1999 and 2004, and after 2004, turning from positive to negative. Having presented the historical evidence, the paper concludes by emphasizing the close interaction between the factors of temporality, interaction and the process of Europeanization in the Turkish context and suggesting that the analysis of these two factors opens up new possibilities for comparative research on other accession and candidate countries.