On-farm field experiments were conducted in the Piedmont Plateau and Coastal Plain of North Carolina in 1981 and 1982 to investigate the integration of sethoxydim {2-[1-(ethoxyimino)butyl]-5-[2-(ethylthio)propyl]-3-hydroxy-2-cyclohexen-1-one} with other chemical and cultural weed control tactics into soybean [Glycine max (L.) Merr.] weed management systems. Sethoxydim at 0.2 kg ai/ha provided control of broadleaf signalgrass [Brachiaria platyphylla (Griseb.) Nash. # BRAPP], large crabgrass [Digitaria sanguinalis (L.) Scop. # DIGSA], and fall panicum [Panicum dichotomiflorum Michx. # PANDI) equal to control achieved with registered rates of the soil-applied herbicides alachlor [2-chloro-2’,6’-diethyl-N-(methoxymethyl)acetanilide] and trifluralin (α,α,α-trifluoro-2,6-dinitro-N,N-dipropyl-p-toluidine). Control of broadleaf weed species with the postemergence herbicides bentazon [3-isopropyl-1H-2,1,3-benzothiadiazin-4-(3H)-one 2,2-dioxide] and acifluorfen {5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoic acid} equaled or exceeded the control obtained with the soil-applied herbicides linuron [3-(3,4-dichlorophenyl)-1-methoxy-1-methylurea] and metribuzin [4-amino-6-tert-butyl-3-(methylthio)-as-triazin-5-(4H)-one]. Applications of 0.22 kg/ha of sethoxydim 2, 3, 4, and 5 weeks after soybean planting provided season-long control of fall panicum and crabgrass in 1981. In 1982, crabgrass control was 88 to 99% up to 4 weeks after planting. Later applications provided inadequate control of the grass species. Variations in volume and pressure of application had no effect on control of 10-cm goosegrass [Eleusine indica (L.) Gaertn. # ELEIN] or broadleaf signalgrass with 0.2 kg/ha of sethoxydim. Increasing pressure increased control of 30-cm goosegrass and broadleaf signalgrass. Increasing volume increased only control of goosegrass. Bentazon and acifluorfen provided better control of broadleaf weeds when applied early than when applied late. In two of four experiments tank mixtures of sethoxydim and bentazon resulted in an initial decrease in grass control compared to corresponding sequential applications. Soybean yields were comparable, however.