This research aims to characterize the mineralogical and crystal-chemical purity of two samples of natural talc (BTT6, BTT7) from the occurrence ‘Ecole1’ in the deposit of Minzanzala, southwest Gabon. X-ray diffraction and modal-composition calculations demonstrated the presence of quartz and Al–Fe-bearing phases (kaolinite and/or chlorite and/or Al–Fe oxyhydroxides) as accessory minerals in both ores. In contrast, the chemical and spectroscopic characterization of the talc component revealed remarkable chemical purity expressed by very low Fe contents. According to these results, the talc of Minzanzala might be used as a filler in a wide range of industrial applications, such as in cosmetics, paints, polymers or ceramics.