Human herpesvirus 6 (HHV-6) is a T-lymphotropic herpesvirus, which infects
almost all children by the age of two years and persists lifelong. Two distinct
variants of HHV-6, HHV-6A and HHV-6B, have been described, and the latter has
been shown to be a common cause of acute febrile illnesses in young children,
including exanthem subitum (roseola). HHV-6 has also been associated with a
number of neurological disorders, including encephalitis and seizures, and the
virus has been postulated to play a role in acquired immunodeficiency syndrome
(AIDS), multiple sclerosis (MS) and chronic fatigue immunodeficiency syndrome
(CFIDS). This review provides a critical summary of research conducted on HHV-6.