This paper deals with the stiffness modeling, analysis and comparison of a Biglide parallel grinder with two alternative modular parallelograms. It turns out that the Cartesian stiffness matrix of the manipulator has the property that it can be decoupled into two homogeneous matrices, corresponding to the translational and rotational aspects, through which the principal stiffnesses and the associated directions are identified by means of the eigenvalue problem, allowing the evaluation of the translational and rotational stiffness of the manipulator either at a given pose or the overall workspace. The stiffness comparison of the two alternative Biglide machines reveals the (dis)advantages of the two different spatial modular parallelograms.