Detrital sediments of the Sea of Galilee are predominantly pedogenic products of settled dust and local bedrocks transported from Upper Galilee and the Golan Heights. Using the mineralogy, chemistry, and Nd and Sr isotope ratios of the core LK12-22 collected offshore of the Ginosar valley and of contemporaneous soils from the Nahal Tzalmon and Nahal Amud catchments, we reconstructed Late Holocene regional hydroclimate. The core samples span ɛNd isotope values of −6 to −2 and 87Sr/86Sr ratios of 0.7075 to 0.7077 between the isotope fields of the Terra rossa soils and basaltic soils. Sediments from the drier Iron Age and Arabic and Ottoman periods are closer in Nd-Sr isotope ratios of the basaltic soils, while those of the wetter Middle to Late Bronze and Roman–Byzantine periods are closer to the Terra rossa soils, reflecting enhanced mobilization of sediments from the Tzalmon catchment where Terra rossa–type soils accumulated. This result corroborates other regional data that indicate semiarid to temperate conditions in the south Levant during most of the Late Holocene. Wetter conditions over the Galilee Mountains and the Ginosar valley catchment during the Roman period could have promoted the flourishing farming-fishing society that heralded the rise of Christianity.