Gaetano Salvemini (1873–1957) is one of the most influential intellectuals of Italian and European twentieth-century history. As 2023 marks the 150th anniversary of Salvemini's birth, this special issue of Modern Italy aims to attract the attention of an international readership and contribute to filling the gap in scholarly publications in English, offering a tool to approach Salvemini's intellectual production and biography. We have chosen to focus on four aspects of Salvemini's life that we consider particularly suitable for introducing his personal trajectory and the evolution of his thinking, adopting a transnational approach: his interpretation of the Great War and the Adriatic question; his antifascist exile in Great Britain and, from 1934, in the United States; and the publication of his most important studies on Fascist Italy. The choice of these topics aims to shed light on Salvemini's contacts and stimulating exchanges with foreign scholars, his international experiences, and how these transformed his ideas on Liberal and Fascist Italy.