Field studies were conducted in Alabama in 1998 and 1999 to evaluate fomesafen preemergence (PRE) in glyphosate-resistant cotton. Fomesafen (0.3 and 0.4 kg ai/ha), fluometuron (1.4 kg ai/ha), and pyrithiobac (0.05 kg ai/ha) were applied alone or in tank mixtures. Glyphosate (0.4 kg ae/ha) was applied postemergence over-the-top (POT) and postemergence directed (PD). Regardless of PRE treatment, POT followed by (fb) PD applications of glyphosate were necessary for greater than 82% sicklepod control at midseason. In the absence of glyphosate, fomesafen, and fomesafen-containing tank mixtures controlled common cocklebur and Ipomoea species 77 and 72%, respectively, 14 d after PD application. However, two applications of glyphosate were needed for >94% season-long control of common cocklebur and Ipomoea species because of continued germination throughout the growing season. Postemergence applications of glyphosate added a 1,000 kg/ha seed cotton yield increase to all PRE treatments at both locations. Common cocklebur, Ipomoea species, and sicklepod control was not significantly increased by the addition of fomesafen PRE tank mixtures fb glyphosate postemergence as compared with glyphosate postemergence only.