Field studies were conducted in 1997 and 1998 to evaluate weed control and soybean (Glycine max) yield with cloransulam and diclosulam. Cloransulam at 35 g/ha applied preplant incorporated (PPI) and preemergence (PRE) controlled at least 91% of hyssop spurge (Euphorbia hyssopifolia) and prickly sida (Sida spinosa) and at least 82% of entireleaf morningglory (Ipomoea hederacea var. integriuscula) and pitted morningglory (Ipomoea lacunosa) at 7 wk after planting. Control of these species with cloransulam was not affected by method of soil application. Control of prickly sida with cloransulam PPI or PRE was better than with cloransulam postemergence (POST) at 18 g/ha. Soybean yields were similar with cloransulam PPI (2,880 kg/ha) or PRE (3,110 kg/ha) and were comparable to imazaquin PRE at 140 g/ha (3,080 kg/ha). Weed control and soybean yields with cloransulam POST were similar to that with chlorimuron POST at 11 g/ha. SAN 582 plus cloransulam PRE followed by cloransulam POST provided the highest soybean yield (3,450 kg/ha). Diclosulam PPI or PRE provided similar levels of control of hyssop spurge, Ipomoea morningglories, and prickly sida. Overall, control of these species with diclosulam PPI or PRE was similar to that obtained with sulfentrazone plus chlorimuron PRE. Soybean yields (≥ 3,290 kg/ha) were similar regardless of method of diclosulam application, and yields were equivalent to that of sulfentrazone plus chlorimuron PRE (3,270 kg/ha).