This article presents 6637 radiocarbon dates from archaeological sites in southernmost Sweden, from 9000 cal bc to the present. Based on summed probability distributions (SPDs) of the calibrated radiocarbon dates, the authors consider long-term trends in settlement and human population. Most dates are from the fertile and densely populated plains of south-western Scania, but coastal lowlands and forested uplands are also represented, allowing for a discussion of the relationship between central and peripheral areas. The authors distinguish between different types of archaeological contexts and features and between different types of dated material, so as to better understand the processes behind population and settlement change. They highlight three periods and phenomena revealed by the SPDs: a strong population increase at the onset of the Neolithic (4000–3700 cal bc), followed by a sharp decline; a steady and long-lasting expansion from the Early Bronze Age to the Roman Iron Age (1500 cal bc–cal ad 200); and a decrease in the Nordic Late Iron Age (seventh century ad), particularly in recently colonized upland areas. The SPDs presented provide a new framework for archaeology in southern Sweden and offer an empirical basis for discussion of long-term trends in settlement and population development.