Experiments were conducted near Scottsbluff, NE in 1991 and 1992 to evaluate the selectivity of imazethapyr for weed control in blue grama, intermediate wheatgrass, little bluestem, Russian wildrye, switchgrass, and western wheatgrass. Imazethapyr reduced weed biomass in all seedings and injured all perennial grasses 12 days after treatment (DAT). Imazethapyr reduced the height of intermediate wheatgrass, Russian wildrye, and switchgrass 35 DAT. Russian wildrye, and switchgrass biomass 50 DAT was reduced by imazethapyr. Weed biomass in new seedings of intermediate wheatgrass and western wheatgrass were reduced more than that of the other grasses.