Red rice at 20 plants m−2 was grown with two rice cultivars for 0, 40, 60, 80, 100, or 120 days after emergence. Red rice interference for 120 days after rice emergence reduced straw dry weights of Lemont and Newbonnet 58 and 34%, respectively. Grain yield of Lemont and Newbonnet was reduced 86 and 52%, respectively, by red rice interference for 120 days after emergence. Regression analyses indicated that red rice interference reduced straw dry weights of Newbonnet and Lemont 25 and 50 kg ha−1 day−1, respectively, for interference durations of 40 to 120 days after emergence. Grain yield of Newbonnet and Lemont was reduced 60 and 93 kg ha−1 day−1, respectively, for interference durations of 60 to 120 days. Negative linear relationships occurred between interference durations of red rice and plant height, panicles m−2, spikelets panicle−1, filled grains panicle−1, or panicle length of both cultivars. However, all parameters were reduced more for Lemont than for Newbonnet as interference duration increased. Head rice (whole kernels) and total milled rice yields of both cultivars were reduced by season-long red rice interference. Red rice straw dry weight and number of culms m−2 were greater when red rice was grown with Lemont than when grown with Newbonnet.