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1 results

  • The distribution on the shortest distance between random cuts on opposite strands of DNA

  • Samuel Litwin
  • Journal:
    Journal of Applied Probability / Volume 11 / Issue 2 / June 1974
    Published online by Cambridge University Press:
    14 July 2016, pp. 363-368
    Print publication:
    June 1974

  • Experiments involving random enzymatic or radioactive multiple cutting of single strands in double stranded DNA will occasionally cut it at pairs of positions on opposite strands that are within about 12 base pairs. In this case the DNA may unravel and come apart. The distribution of closest opposing breaks as a function of λ, the incidence of breaks per unit length, is obtained and graphs of the probability of critical distances as functions of λ are plotted. It is shown that for very large λ the distance between closest opposite breaks is approximately exponential with parameter ½λ2.