The article explores the Legon School of International Relations (LSIR) which is the research, teaching, and academic programming of International Relations (IR) at the University of Ghana, Legon. The LSIR came out of attempts to decolonise knowledge production, dissemination, and academic programing in Ghana in early 1960s. The article shows that the LSIR is decolonial in theoretical perspective, grounded in southern epistemologies, relational in ontology, qualitative in methodology, practice-based, and it is equity-oriented. Although the LSIR scholarship as a package is distinctive, some of its ideas overlap with the work of several contemporary IR communities in the West. The article highlights implications of the LSIR story for the IR communities in the West and the value of paying close attention to the works of IR centres of scholarship in Africa.