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pluripotent stem cells

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Chapter 16 - The Prospects of Infertility Treatment Using “Artificial” Eggs
- By Katsuhiko Hayashi
Edited by Gianpiero D. Palermo, Zsolt Peter Nagy
Book:

Manual of Intracytoplasmic Sperm Injection in Human Assisted Reproduction

Published online:

02 December 2021

Print publication:

25 November 2021, pp 154-160
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Summary

The female germline undergoes a unique sequence of differentiation processes that finally endows the eggs with totipotency. The reconstitution in vitro of oogenesis using pluripotent stem cells, which eventually produces “artificial eggs,” has long been sought in reproductive biology and medicine, as this would contribute not only to a better understanding of the basic mechanisms underlying totipotency, but also to an alternative source of gametes for reproduction. This chapter introduces a scientific background, the current status and the prospects of artificial eggs in mice and humans.