Field and greenhouse studies were conducted to investigate the compatibility of MSMA in a tank mixture with glyphosate or glufosinate for broadleaf and grass weed control. Glyphosate, glufosinate, and MSMA were evaluated at 0.5×, 1×, and 2× rates, with 1× rates of 0.84 kgae/ha, 0.5 kgai/ha, and 2.2 kgai/ha, respectively. Glyphosate and glufosinate provided similar levels of control for most weed species and were often more efficacious than MSMA alone. Glyphosate controlled Palmer amaranth better than glufosinate. Glufosinate controlled hemp sesbania, pitted morningglory, and ivyleaf morningglory better than glyphosate at one location. Weed control was not improved with the addition of MSMA to glyphosate or glufosinate when compared with either herbicide alone. MSMA antagonized glyphosate efficacy on barnyardgrass, browntop millet, hemp sesbania, Palmer amaranth, and redroot pigweed. MSMA antagonized glufosinate efficacy on browntop millet, hemp sesbania, ivyleaf morningglory, johnsongrass, Palmer amaranth, pitted morningglory, prickly sida, redroot pigweed, and velvetleaf. Antagonism of glyphosate or glufosinate by MSMA was often overcome by applying the 2× rate of either herbicide alone. MSMA is not a compatible tank-mixture partner with glyphosate or glufosinate for weed control in cotton.