Field studies were conducted from 1987 through 1990 on Sharkey clay to determine effect of weed control treatment (WTRT) on yield and net return from soybean grown with no irrigation (NI) or irrigation (I) during reproductive development. Weed control treatments were: 1) PRE glyphosate plus metribuzin plus metolachlor or pendimethalin, followed by POST bentazon plus acifluorfen or 2,4-DB plus linuron (high WTRT); 2) PRE glyphosate at a rate to kill existing weeds at planting (medium WTRT); or 3) PRE paraquat at a rate to desiccate but not necessarily kill existing weeds at planting (low WTRT). POST cultivation was used in all treatments. Weed ground cover in the high, medium, and low WTRT's was composed of annual grass and moderately competitive broadleaf species, and averaged 7, 25, and 49%, respectively, at harvest in 1990. Yield declined with decreasing weed control in the I treatment after the first year, but average net returns from the high and medium WTRT's were not different, and both exceeded average returns from the low WTRT. Yields from the high and medium WTRT's in the NI treatment were not different, and both exceeded yield from the low WTRT. Average net returns from the medium WTRT were greater than those from the high and low WTRT's in all years. Yield increase from irrigation and difference in average net returns between I and NI declined with decreasing weed control.