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3 results

  • Dual pathology: cervicofacial actinomycosis and nicorandil-induced oral ulceration

  • H E V Cupples, D T McGahey
  • Journal:
    The Journal of Laryngology & Otology / Volume 122 / Issue 4 / April 2008
    Published online by Cambridge University Press:
    14 May 2007, pp. 422-424
    Print publication:
    April 2008
  • Introduction:

    Oral ulceration has many causes and is a common presenting symptom in otolaryngology.

    Case report:

    This article presents an unusual case of dual pathology oral ulceration in an elderly patient. Oral malignancy was initially suspected, but the history, examination and investigation showed that the oral ulceration was caused by actinomycosis infection and by nicorandil use.

    Discussion:

    Cervicofacial acinomycosis is a rare, suppurative bacterial disease in which abscesses can form in the tissues and break through the skin, creating pus-discharging lesions. Nicorandil is a potassium channel blocker used in the treatment of ischaemic heart disease. It has been recently recognised as a cause of persistent ulcerative stomatitis.

    Conclusion:

    This case highlights the importance of a high index of suspicion for unusual and reversible causes of oral ulceration, and of dual pathology as a cause. Such vigilance enables early recognition and treatment of potentially reversible conditions.

  • Oral ulcers caused by hydroxyurea

  • Vinidh Paleri, Leon Lindsey
  • Journal:
    The Journal of Laryngology & Otology / Volume 114 / Issue 12 / December 2000
    Published online by Cambridge University Press:
    08 March 2006, pp. 976-977
    Print publication:
    December 2000

  • We present a case of oral ulceration in a patient with essential thrombocythaemia, that proved to be secondary to treatment with hydroxyurea. This complication has not yet been reported in the ENT literature. Hydroxyurea should be considered as a possible cause of persistent oral ulceration in patients with haematological conditions. It should be noted that the onset of this complication is not related to the dose and duration of therapy.