Following the prototype of Mexico’s Progresa program, a number of countries in Latin America and the Caribbean have initiated conditional cash transfer (CCT) programs. More recently, countries in Sub-Saharan Africa (SSA) have followed suit. However, no comprehensive framework to carry out a cost-benefit analysis (CBA) exists. This paper presents such a CBA framework for CCTs which enables design features such as targeting and conditionality to be separately evaluated. The framework is applied to an evaluation of a CCT program for orphans and vulnerable children in Kenya. The role of conditionality in SSA and the need for distribution weights is discussed.