Ubiquitous Holocene dune systems are associated with major west-to-east flowing rivers across the Southern Great Plains (SGP), USA. Critical questions remain as to whether aeolian activity reflects multiple environmental signatures, including increased sand supply from riverine sources. This research focused on the western Red River where geomorphic mapping revealed three terrace levels up to 16 m, buried partially by up to 10 m of aeolian sediments. Pedosedimentary facies analyses of sections and Geoprobe cores extracted from terraces and close-interval optically stimulated luminescence dating of quartz grains revealed two periods of fluvial aggradation at ca. 80 ka to ~5 to 8 m above the Red River forming the Vernon terrace, and at 30 to 13 ka to ~20–15 m, the highest identified Childress terrace. Net degradation of 20 m also occurred between 13 and 7 ka to 4 m below the current channel, reflecting regional fall in the groundwater level. The latest aggradation event, which built the lowest Luna terrace at ~2 m, ended 1.5 to 0.7 ka and was partially buried by fluvial-sourced dunes in the sixteenth and seventeenth centuries. This recent phase of aeolian deposition coincides with a comparatively wet period in the central United States during the Little Ice Age, rather than with regional drying.