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2 results

  • Chapter 37 - Therapeutic Drug Monitoring

  • from Part 9 - Calculations
  • Edited by Hugh Montgomery, Robert Shulman, Mayur Murali
  • Book:
    Surviving Prescribing
    Published online:
    08 June 2020
    Print publication:
    25 June 2020, pp 159-170

  • Summary

    Therapeutic drug monitoring is performed to ensure drug levels in the blood are in the therapeutic (not toxic) range, thus imporving efficacy of the drug and patient outcomes. While not all drugs require this, those that do have a recognised desired serum concentration which provides optimal effect. The chapter describes some general rules, including when to take levels and how to calculate ideal and corrected body weight, and runs through some common examples, including gentamicin, phenytoin and aminophylline.

  • Chapter 12 - Paracetamol Overdose

  • from Part 3 - Emergency Prescribing
  • Edited by Hugh Montgomery, Robert Shulman, Mayur Murali
  • Book:
    Surviving Prescribing
    Published online:
    08 June 2020
    Print publication:
    25 June 2020, pp 49-52

  • Summary

    Paracetamol overdose is common and potentially life-threatening, causing severe hepatocellular failure, acute renal tubular necrosis and death. This chapter lists top tips for its management through metabolic manipulation or decreasing absorption of the drug. Time from ingestion is key, and the reader is provided with treatment strategies based on time of presentation.