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1 results

  • Results of balloon pulmonary valvoplasty in children with Noonan’s syndrome

  • Jonathon Holzmann, Shane M. Tibby, Eric Rosenthal, Shakeel Qureshi, Gareth Morgan, Thomas Krasemann
  • Journal:
    Cardiology in the Young / Volume 28 / Issue 5 / May 2018
    Published online by Cambridge University Press:
    10 January 2018, pp. 647-652

  • Pulmonary valve stenosis is common in patients with Noonan’s syndrome. The response to balloon valvoplasty varies.

    We assessed the correlation between re-intervention rate, immediate response, and the progress of the valve gradient over time after intervention.

    Methods

    This is a retrospective study conducted from 1995 to 2014.

    Results

    Of 14 patients identified, seven had re-intervention 28±54 months (range 3–149, median 3.3) after valvoplasty. These patients did not have a significant decrease in gradient after intervention. Their gradient subsequently decreased during follow-up and then became static before increasing years after intervention. In contrast, the gradient of patients not requiring further intervention continually reduced over time. Demographics did not differ between these groups.

    Conclusion

    We could not identify predisposing factors for long-term success of pulmonary valvoplasty in Noonan’s patients, but the trajectory of gradients differs significantly between patients needing re-intervention from those who remain free from re-intervention.