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neurotrophism

The Journal of Anatomy (1)

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Neurite outgrowth-regulating properties of GABA and the effect of serum on mouse spinal cord neurons in culture
MARGARET BIRD, ALUN OWEN
Journal:

The Journal of Anatomy / Volume 193 / Issue 4 / November 1998

Published online by Cambridge University Press:

01 November 1998, pp. 503-508

Print publication:

November 1998
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Time-lapse photography was used to examine the effects of γ-aminobutyric acid (GABA) on the outgrowth and motility of neurites in cultures from mouse spinal cord. GABA at concentrations of 100, 10 and 1 μm caused significant inhibition of neurite outgrowth and the motility of growth cones was significantly reduced by treatment with 100 and 10 μm GABA. This effect was mimicked by the GABAB receptor agonist baclofen, whereas the GABAA receptor agonist muscimol had no effect. The effect of GABA on outgrowth and motility seems to be dependent on the type of serum employed. The results reported here were obtained only when heat-inactivated serum was used and not when non heat-inactivated serum was added to the culture medium. They suggest that GABA has a role in the regulation of process outgrowth within the embryonic mouse spinal cord.