This article argues for the importance of reframing the history of school desegregation in the United States beyond Black and white and beyond the regional frames through which this history has been interpreted. In Western states, most Latino children attended schools segregated not by law but by custom starting in the early twentieth century; Latino students also encountered de facto segregation in the Eastern and Midwestern cities with large Puerto Rican populations by the 1950s. Parents, students, advocates, and activists protested the inequality of educational outcomes for Latino children over many decades, developing distinctive strategies to address the combination of racial and language-based discrimination faced by Latino students. Yet, because they were marginalized in political debates in the 1960s and 1970s and because most national-level historical scholarship on school desegregation focuses on Black and white participants, Latinos’ role in this aspect of our national civil rights history has remained obscured.