Use of organic mulch is one of the most common methods of weed control in landscape planting beds and provides other benefits, including improved soil characteristics, increased growth of ornamental plants, and enhanced property aesthetics. In the landscape maintenance industry, it is common to apply mulch and herbicides concurrently to landscape beds to provide long-term, broad-spectrum weed control. It is known that herbicides behave differently when applied to different soil types and organic materials; however, research is lacking concerning which herbicides are most effective with different mulch materials in the landscape. Determining the most effective herbicide–mulch combinations could potentially improve weed control, reduce labor costs from hand weeding, and mitigate negative environmental impacts resulting from off-site herbicide movement. The objective of this paper is to review the research that has been conducted pertaining to various mulch–herbicide combinations in the landscape and in other areas of agricultural production while also identifying key knowledge gaps that should be addressed in future research. Review of the literature suggests satisfactory weed control can be achieved with high mulch depths (≥ 7 cm) regardless of herbicide use, and herbicide–mulch interactions become more pronounced as mulch depth decreases. Additionally, future research is needed to determine which herbicides are best suited for different mulch types to improve weed control and potentially reduce environmental impacts, including herbicide leaching and runoff into urban and suburban waterbodies.