Field studies were conducted in the northern and southern cane belt areas of Louisiana to determine the effect of itchgrass on sugarcane growth and yield. Itchgrass was allowed to interfere with sugarcane season-long, early-season from emergence in the spring until layby (last cultivation) in mid-June, and late-season from layby until harvest. Itchgrass germination occurred throughout the growing season. Populations of millable sugarcane stalks and yields of cane and sugar were similar for no interference, early-, and late-season interference. Season-long itchgrass interference reduced sugarcane stalk populations and cane and sugar yields an average of 34, 42, and 43%, respectively, compared with no interference.