Topographic models of the late Quaternary landscape prior to isostatic rebound aid interpretation of glacial lake-water levels and geomorphic features as well as ice thickness, mantle viscosity and lithospheric strength. The well-established limit of glacial marine inundation in central and northern New England provides a test of total isostatic depression. Relative sea levels reflecting differing magnitudes of isostatic rebound show that published values of isostatic depression in southern New England would inundate the landscape in southern New England with marine water south of the limit of late Pleistocene marine inundation. This suggests that isostatic depression at the terminal margin of the Laurentide Ice Sheet (LIS) was < 35 m, and that previous workers overestimate isostatic depression in southern New England by > 50 m. A first-order estimate of ice thickness based on total isostatic depression and the observed uplift profile in southern New England supports the ‘thin ice’ models in New England. Ice thickness ranged from 100 m at the southeastern margin of the LIS, to > 1000 m at a point 300 km north of the terminal margin. This regional model places constraints on continental ice-sheet and geophysical models that should be considered in the future.