This article argues that we need to move beyond the “Atlantic” and “formal” bias in our understanding of the history of slavery. It explores ways forward toward developing a better understanding of the long-term global transformations of slavery. Firstly, it claims we should revisit the historical and contemporary development of slavery by adopting a wider scope that accounts for the adaptable and persistent character of different forms of slavery. Secondly, it stresses the importance of substantially expanding the body of empirical observations on trajectories of slavery regimes, especially outside the Atlantic, and most notable in the Indian Ocean and Indonesian Archipelago worlds, where different slavery regimes existed and developed in interaction. Thirdly, it proposes an integrated analytical framework that will overcome the current fragmentation of research perspectives and allow for a more comparative analysis of the trajectories of slavery regimes in their highly diverse formal and especially informal manifestations. Fourth, the article shows how an integrated framework will enable a collaborative research agenda that focuses not only on comparisons, but also on connections and interactions. It calls for a closer integration of the histories of informal slavery regimes into the wider body of existing scholarship on slavery and its transformations in the Atlantic and other more intensely studied formal slavery regimes. In this way, we can renew and extend our understandings of slavery's long-term, global transformations.