The Sun moves with respect to the local interstellar medium (LISM) and modifies its properties to heliocentric distances as large as 1 pc. The solar wind (SW) is affected by penetration of the LISM neutral particles, especially H and He atoms. Charge exchange between the LISM atoms and SW ions creates pickup ions (PUIs) and secondary neutral atoms that can propagate deep into the LISM. Neutral atoms measured at 1 au can provide us with valuable information on the properties of pristine LISM. Voyager 1 and 2 spacecraft perform in situ measurements of the LISM perturbed by the presence of the heliosphere and relate them to the unperturbed region. We discuss observational data and numerical simulations that shed light onto the mutual influence of the SW and LISM. Physical phenomena accompanying the SW–LISM interaction are discussed, including the coupling of the heliospheric and interstellar magnetic field at the heliopause.
