This article covers the preconditions, causes, and consequences of the famine of 1921–1923 and of the Holodomor of 1932–1933. Significant attention is paid to the geography and scale of the famine. For the first time in the historiography of the famine of 1921–1923, a thorough assessment is conducted of the demographic loss of population for Ukraine as a whole, seven oblasts, and the Moldova Autonomous Soviet Socialist Republic (ASSR). A comparative analysis of the research results of the 1921–1923 famine and the Holodomor of 1932–1933 is presented. The discussion consists of three parts. The first part addresses the famine of 1921–1923. It examines the historico-political and economic context of the famine, its scale, and its uneven effect on different parts of the country. Special attention is paid to the sanitary-epidemiological situation which was closely tied to the famine itself. The second part is devoted to the Holodomor of 1932–1933. A comparative analysis of losses during the famines of 1921–1923 and 1932–1933 is presented in the third part.