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hepatocerebral degeneration

Cambridge University Press (1)

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Chapter 14 - The Liver–Brain Relationship in Wilson Disease
Robert Laureno, Georgetown University, Washington DC
Book:

Insights into Clinical Neurology

Published online:

27 July 2023

Print publication:

20 July 2023, pp 72-74
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Summary

The neuropathology of Wilson disease resembles that of chronic nonfamilial hepatocerebral disease. The neurological features of the hereditary disease also resemble those of the nonfamilial disease. Liver transplantation improves both the lesions on MRI scans and the neurologic disorder of Wilson disease. For these reasons and others there is no reason to invoke copper toxicity in the pathogenesis of Wilsonian hepatocerebral disease.