In full-season soybean experiments, adding glyphosate, paraquat, or HOE-0661 to chlorimuron, chlorimuron plus linuron, chlorimuron plus metribuzin, or imazaquin was required for effective weed control, especially eastern black nightshade. In double-crop soybean experiments, chlorimuron plus linuron provided similar weed control and yields with or without either glyphosate, paraquat, or HOE-0661. In both full-season and double-crop soybeans, metolachlor combined with chlorimuron mixtures did not enhance weed control or increase yield. These studies indicate a potential for reducing the use of nonselective herbicides or metolachlor when chlorimuron or imazaquin are components of tank mixes, particularly in double-crop no-till soybeans.