This article presents a new interpretation of the reign of the Ottoman sultan Mehmed the Conqueror (r. 1444–46, 1451–81) as refracted through the twin historical lenses of Mughal South Asia and the Renaissance Mediterranean. On the one hand, it argues that Mehmed, despite his current reputation as a conquering hero of Islam, in fact aspired to a model of sovereignty analogous to Akbar's Sulh-i Kull, and with a common point of origin in the conceptual worlds of post-Mongol Iran and Timurid central Asia. On the other hand, it also draws from the historiography of the Italian Renaissance to interpret Mehmed's cultural politics as being simultaneously inspired by a particular thread of Renaissance philosophy, the Prisca Theologia, which in many ways served as the Ottoman equivalent of Akbar's Sulh-i Kull.