The study was conducted to determine the cross-resistance of imazethapyr-resistant common sunflower (Helianthus annuus) to selected imidazolinone, sulfonylurea, and triazolopyrimidine herbicides. Whole-plant herbicide dose–response curves and in vitro enzyme studies showed that imazethapyr-resistant common sunflower was highly resistant to imazamox, slightly resistant to thifensulfuron and chlorimuron, and not resistant to cloransulam. Resistance ratios of herbicide concentrations required to inhibit growth by 25% were 310, 3.3, 2.0, and 1.4 times greater in the resistant biotype than in the susceptible biotype for imazamox, thifensulfuron, chlorimuron, and cloransulam, respectively. Similarly, herbicide concentrations required to inhibit ALS activity in vitro by 25% were 332.0, 18.6, 8.3, and 1.2 times greater in the resistant biotype than in the sensitive biotype for imazamox, chlorimuron, thifensulfuron, and cloransulam, respectively.