Johannes Hoornbeeck (1617–1666) was a Dutch Protestant theologian, generally regarded as a member of the so-called Further Reformation in the Netherlands. He wrote a number of theological works in Latin and in Dutch. Most of his works have a polemical character, defending his orthodox protestant stance against a variety of heretical views. In De conversione Indorum et gentilium, based on disputations with students and published posthumously, he enters into a discussion with the ‘heathens’. To this end he carefully combines biblical and classical scholarship and also reflects on the latest ethnographical information collected by both Protestant and Catholic travellers and missionaries. The book is characterised by great erudition and by an openness for other people’s opinions that necessitates the constant appraisal of one’s own point of view. We argue that such an open engagement with heretical views ultimately carries the danger of a sceptical view of one’s own religion.