Palmer amaranth is a common weed on levees in rice fields but has become increasingly problematic with the adoption of furrow-irrigated rice and lack of an established flood. Florpyrauxifen-benzyl previously has been found effective for controlling Palmer amaranth in rice, but the efficacy of low rates of florpyrauxifen-benzyl and the effect of Palmer amaranth size on controlling it is unknown. The objective of this research was to determine the level of Palmer amaranth control expected with single and sequential applications of florpyrauxifen-benzyl at varying weed heights. The first study was conducted near Marianna, AR, in 2019 and 2020, to determine the effect of florpyrauxifen-benzyl rate on control of <10 cm (labeled size) and 28- to 32-cm-tall (larger-than-labeled size) Palmer amaranth. The second experiment was conducted in 2020 at two locations in Arkansas to compare single applications of florpyrauxifen-benzyl at low rates to sequential applications at the same rates with a 14-d interval on 20- and 40-cm-tall Palmer amaranth. Results revealed that florpyrauxifen-benzyl at 15 g ae ha−1 was as effective as 30 g ae ha−1 in controlling <10-cm-tall Palmer amaranth (92% and 95% mortality in 2019). Sequential applications of florpyrauxifen-benzyl at 8 g ae ha−1 were as effective as single or sequential applications at 30 g ae ha−1. However, no rate of florpyrauxifen-benzyl applied to 20- or 40-cm-tall Palmer amaranth was sufficient to provide season-long control of the weed, with the escaping female plants producing as many as 6,120 seed per plant following a single application.