We address the issue of parameter variations in POD approximations of time-dependentproblems, without any specific restriction on the form of parameter dependence.Considering a parabolic model problem, we propose a POD construction strategy allowing usto obtain some a priori error estimates controlled by the POD remainder –in the construction procedure – and some parameter-wise interpolation errors for the modelsolutions. We provide a thorough numerical assessment of this strategy with theFitzHugh − Nagumo 1D model. Finally, we give detailed illustrations of the approach in twoparameter estimation applications, the first in a variational estimation framework withthe FitzHugh − Nagumo model, and the second with a beating heart mechanical model forwhich we employ a sequential estimation method to characterize model parameters using realimage data in a clinical case.
