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end-plate zone

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Chapter 5 - The Neuromuscular Junction
John A. Jarratt, Emeritus, Sheffield Teaching Hospitals NHS Foundation Trust
Book:

Essential Electromyography

Published online:

14 September 2023

Print publication:

05 October 2023, pp 14-15
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Summary

The end-plate zone of muscle contains neuromuscular junctions. This simplified account of their structure and function is designed to aid an understanding of repetitive nerve stimulation testing and single-fibre electromyography, detailed later in the book. The anatomy of the synaptic bulb containing acetylcholine-filled vesicles is described. These are discharged into the synaptic cleft by the process of exocytosis. Small quantities which occur spontaneously produce end-plate potentials but larger quantities following depolarisation of the synaptic bulb will generate a muscle action potential.