The Black Death is a secure feature of European and west Asian history; in Chinese history, by contrast, the record of mass epidemic outbreaks over the same centuries is not. As a step towards integrating these two zones into a global history of disease, this article establishes a timeline of roughly a thousand major outbreaks in Ming–Qing China during the century 1567–1666. On the basis of these data, comparison is made of how pandemics were received and interpreted in two delimited zones, the Chinese province of North Zhili (now Hebei) and Tudor and Stuart England, with particular attention to differences in their literary incorporation, religious meaning, and political resonance.