Methyl bromide (MeBr), a widely used soil fumigant in tomato production, has been banned for ordinary agricultural uses. In the absence of MeBr, a viable alternative is imperative for weed control and prevention of economic loss in tomato production. A field study was conducted in the summers of 2010 and 2011 at Fayetteville, AR, to compare the efficacy and economics of herbicide programs consisting of pre-transplant followed by (fb) post-transplant herbicides in low-density polyethylene (LDPE) mulched tomato. Pre-transplant imazosulfuron at 0.112, 0.224, and 0.336 kg ai ha−1 and S-metolachlor at 1.6 kg ai ha−1 were fb a post-transplant mixture of trifloxysulfuron plus halosulfuron at 0.008 and 0.027 kg ai ha−1 at 4 wk after transplant (WATP). The standard MeBr treatment (2:1 mixture of MeBr plus chloropicrin at 390 kg ai ha−1), weed-free (hand weeding) control, and nontreated weedy check were used for comparison. Pre-transplant S-metolachlor fb post-transplant herbicides controlled Palmer amaranth ≥ 89%, large crabgrass ≥ 88%, and yellow nutsedge ≥ 90%, which was comparable to the control with MeBr. Tomato recovered the injury (≤ 19% at 6 WATP) from post-transplant herbicides in the later weeks. S-metolachlor–containing herbicide programs yielded marketable tomato fruit comparable to the yield with MeBr. Economic evaluation of the herbicide programs demonstrated a net return of $3,758.50 ha−1 from the S-metolachlor–containing herbicide program in LDPE-mulched tomato. Likewise, this herbicide program showed minimum loss of ≤ $671.61 ha−1 in net return relative to MeBr. In conclusion, a herbicide program consisting of pre-transplant S-metolachlor fb post-transplant trifloxysulfuron plus halosulfuron is a viable alternative to MeBr for weed control and marketable yield in LDPE-mulched tomato production.