Results of stratigraphic and morphotectonic analyses on fluvial terraces at the outlet of the Meduna valley in the eastern Southern Alps are used to investigate on the tectonics and paleoclimate. The Meduna valley, prone to destructive earthquakes, belongs to the front of the eastern Southern Alps, a south-verging fold and thrust belt in evolution from the Middle Miocene to the present, constructed by ENE–WSW striking, SSE-verging medium to low-angle thrusts, gradually propagating in the Venetian–Friulian plain. In the study area, located south of the Periadriatic thrust, the main structural element is the ENE–WSW striking Maniago–M. Jouf thrust system. Seven depositional units, ranging in age from Pliocene to Holocene, and a hierarchy of four numbered terrace complexes were identified. Stratigraphic and geometric relationships between sedimentary units, basal surfaces and terraces allow the reconstruction of the chronology of the depositional events. The study shows that the valley configuration has been shaped during the Pliocene–Quaternary with long-lasting steady intervals, interspaced with periodic tectonic pulses of the thrust front of the eastern Southern Alps. The most recent pulse related to the Maniago thrust shows an upper Pleistocene–Holocene slip rate of about 0.6 mm/yr.