With the shift to earlier maturing soybean cultivars, harvest interference data are needed at low weed densities that will not reduce yield, but may affect soybean quality or harvesting efficiency. Field experiments were conducted in 1995 and 1996 to determine the density of five weeds necessary to warrant desiccation treatments. There were no consistent differences in losses of harvestable soybean due to weed density. Common cocklebur increased foreign material and soybean moisture at a greater rate than did hemp sesbania, ivyleaf morningglory, or redroot pigweed, with sicklepod intermediate among these species. Soybean test weight was reduced by 17, 13, and 59 g/L for each plant/meter of row with redroot pigweed, sicklepod, and common cocklebur, respectively, whereas hemp sesbania and ivyleaf morningglory did not affect test weight. However, all species evaluated increased damaged soybean seeds by 8.2 to 11.1% for each plant/meter of row. Combine speed was not affected substantially by the weed densities evaluated.