Human history has been marked by major episodes of climate change and human response, sometimes accompanied by independent innovations. In the Bronze Age, the sequencing of causes and reactions is dependent in part on dendrochronology and radiocarbon dating. This paper explores the interaction of a major, prolonged desiccation event between c. 2300 and 2000 BC and human agency including migrations, the displacement of trading networks, warfare, the appearance of weapons made of bronze, and the first appearance of sailing vessels in the Mediterranean.