Polka-dot ribbonfish Desmodema polystictum was recorded for the first time from Indian waters. A single specimen of D. polystictum (107 cm total length and weighing 480 g) was collected from Tharuvaikulam landing centre, north to Tuticorin, on the south-east coast of India during September 2010. The distinguishing characters of the species from other species of the family are discussed. Morphometric and meristic characters of D. polystictum are presented in this paper. With the present report, the distribution area of this species now extends to the Indian waters.