Optical coherence tomography (OCT) and confocal microscopy are pivotal in retinal imaging, offering distinct advantages and limitations. In vivo OCT offers rapid, noninvasive imaging but can suffer from clarity issues and motion artifacts, while ex vivo confocal microscopy, providing high-resolution, cellular-detailed color images, is invasive and raises ethical concerns. To bridge the benefits of both modalities, we propose a novel framework based on unsupervised 3D CycleGAN for translating unpaired in vivo OCT to ex vivo confocal microscopy images. This marks the first attempt to exploit the inherent 3D information of OCT and translate it into the rich, detailed color domain of confocal microscopy. We also introduce a unique dataset, OCT2Confocal, comprising mouse OCT and confocal retinal images, facilitating the development of and establishing a benchmark for cross-modal image translation research. Our model has been evaluated both quantitatively and qualitatively, achieving Fréchet inception distance (FID) scores of 0.766 and Kernel Inception Distance (KID) scores as low as 0.153, and leading subjective mean opinion scores (MOS). Our model demonstrated superior image fidelity and quality with limited data over existing methods. Our approach effectively synthesizes color information from 3D confocal images, closely approximating target outcomes and suggesting enhanced potential for diagnostic and monitoring applications in ophthalmology.

Wind energy’s ability to liberate the world from conventional sources of energy relies on lowering the significant costs associated with the maintenance of wind turbines. Since icing events on turbine rotor blades are a leading cause of operational failures, identifying icing in advance is critical. Some recent studies have utilized deep learning (DL) techniques to predict icing events with high accuracy by leveraging rotor blade images, but these studies only focus on specific wind parks and fail to generalize to unseen scenarios (e.g., new rotor blade designs). In this paper, we aim to facilitate ice prediction on the face of lack of ice images in new wind parks. We propose the utilization of synthetic data augmentation via a generative artificial intelligence technique—the neural style transfer algorithm to improve the generalization of existing ice prediction models. We also compare the proposed technique with the CycleGAN as a baseline. We show that training standalone DL models with augmented data that captures domain-invariant icing characteristics can help improve predictive performance across multiple wind parks. Through efficient identification of icing, this study can support preventive maintenance of wind energy sources by making them more reliable toward tackling climate change.